The recommended 5-Amino-1MQ dosage for subcutaneous (subQ) injection ranges from 150-500 mcg daily. For beginners, start with 150 mcg daily for the first week to assess tolerance. Alternatively, oral capsules are available but have significantly lower bioavailability. Dosage for capsules is 50-100 mg daily, divided into 1-2 doses.
What is 5-Amino-1MQ?
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective NNMT inhibitor that boosts NAD+ levels, enhancing mitochondrial function and fat oxidation. It’s used in metabolic research for weight management and energy production.
Dosage Protocols
Beginner (Weeks 1-2)
- Dose: 150 mcg subQ
- Timing: Morning, fasted
- Frequency: Once daily
Adaptation minimizes side effects; expect mild energy boosts.
Standard (Weeks 3-8)
- Dose: 300 mcg subQ
- Timing: Morning, pre-meal
- Frequency: Once daily
Optimal for NNMT inhibition and fat loss.
Advanced (Weeks 9-12)
- Dose: 500 mcg subQ (split 250 mcg AM/PM)
- Frequency: Twice daily
- Duration: 8-12 weeks, monitored
For metabolic resistance; higher users report up to 1 mg in stacks.
Weight-Based Dosing
- <150 lbs: 150-300 mcg daily
- 150-200 lbs: 300 mcg
- >200 lbs: 300-500 mcg
- Obese: May require higher doses, supervised
Administration Guidelines
Injection Method
SubQ for best absorption; oral less effective due to metabolism.
Sites
- Abdomen (2″ from navel)
- Thighs/arms
- Rotate to avoid irritation
Needles
- 29-31G insulin syringes
- 0.5-1 mL, ½” length
Reconstitution (10 mg Vial)
- Add 2 mL bacteriostatic water (0.9% benzyl alcohol).
- Swirl gently (no shaking).
- Yields 5 mg/mL; refrigerate up to 30 days.
Storage
- Lyophilized: Room temp, dark
- Reconstituted: 2-8°C; use within 30 days
Timing and Cycling
- Timing: Morning, fasted for lipolysis synergy.
- Cycles: 8 weeks on/4 off (standard); 6 on/3 off (conservative); 12 on/6 off (extended). Prevents tolerance.
FAQs
Beginner dose? 150 mcg subQ for 1-2 weeks, then 300 mcg.
Fat loss dose? 300 mcg daily; up to 500 mcg if needed.
Side effects? Minimal: mild energy surge, site irritation, nausea at higher doses. Avoid >500 mcg to prevent overstimulation.
Cycle length? 8-12 weeks on, 4-6 off.
Metabolic enhancement? 300 mcg daily; start lower for syndrome.
Safety and Contraindications
Avoid if: Pregnant/breastfeeding, CVD, severe organ dysfunction, eating disorders, <21 years.
Interactions: Stimulants, BP/diabetes meds, MAOIs.
Consult provider for: Conditions, meds, symptoms.
Comparisons and Stacking
Vs. NAD+ precursors: Inhibits degradation for sustained effects.
Stacks: Semaglutide (weight loss), Tesamorelin (composition), NAD+ IV (energy). Avoid initial stimulants.
Cost-Effectiveness
- 150 mcg: Beginner/maintenance
- 300 mcg: Balanced
- 500 mcg: Goal-specific
Quality Tips
Seek third-party tested, lab-verified sources to avoid impurities.
Monitoring
- Weeks 1-2: Energy, sites
- 3-4: Composition, sleep
- 5+: Progress, markers
Optimal signs: Steady energy, fat loss, performance gains, no jitters.
Adjust: Increase if no effects (after 2 weeks); decrease for stimulation/digestion issues.
Recommendations
- Start at 150 mcg.
- Titrate by 150 mcg weekly.
- Track effects.
- Cycle properly.
- Pair with exercise/nutrition/sleep.
Professional Recommendations
Based on our clinical experience and current research, we recommend:
- Start Conservative: Begin with 150 mcg daily regardless of goals
- Progress Gradually: Increase by 150 mcg increments weekly as needed
- Monitor Closely: Track both benefits and any adverse effects
- Cycle Appropriately: Maintain 8-12 week cycles with proper breaks
- Combine Strategically: Integrate with comprehensive lifestyle optimization
For personalized 5-Amino-1MQ dosing protocols tailored to your specific goals and medical history, consider scheduling a consultation with our medical team. We provide comprehensive assessments, custom protocols, and ongoing monitoring to ensure optimal results while maintaining safety.
Individual responses to 5-Amino-1MQ vary significantly, and what works optimally for one person may require adjustment for another. Professional guidance helps navigate these individual differences while maximizing therapeutic benefits.
